TY - JOUR AU - Pankiewicz, Joanna E. AU - Diaz, Jenny R. AU - Martá-Ariza, Mitchell AU - Lizińczyk, Anita M. AU - Franco, Leor A. AU - Sadowski, Martin J. PY - 2020 DA - 2020/09/09 TI - Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis JO - Molecular Neurodegeneration SP - 50 VL - 15 IS - 1 AB - Disruption of β-amyloid (Aβ) homeostasis is the initial culprit in Alzheimer’s disease (AD) pathogenesis. Astrocytes respond to emerging Aβ plaques by altering their phenotype and function, yet molecular mechanisms governing astrocytic response and their precise role in countering Aβ deposition remain ill-defined. Peroxiredoxin (PRDX) 6 is an enzymatic protein with independent glutathione peroxidase (Gpx) and phospholipase A2 (PLA2) activities involved in repair of oxidatively damaged cell membrane lipids and cellular signaling. In the CNS, PRDX6 is uniquely expressed by astrocytes and its exact function remains unexplored. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-020-00401-8 DO - 10.1186/s13024-020-00401-8 ID - Pankiewicz2020 ER -