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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

Fig. 6

Expression of TREM2 in plaque-associated microglia shows direct relationship with Prdx6 gene dose. a Representative LSCM images of mature plaques co-labeled with X-34 (fibrillar core), anti-Iba1, and anti-TREM2 antibodies from female animals of indicated genotypes evidence increased periplaque expression of TREM2 in APP/Prdx6Tg line and conversely reduced expression in APP/Prdx6+/− line compared to APP/Prdx6+/+ controls. Quantification of TREM2 immunoreactivity within surrounding of the X-34+ fibrillar core (TREM2 plaque area) b and TREM2 to Iba1 ratio in plaque-associated microglia c. Values represent mean (+SEM) from n = 45 randomly selected plaques per genotype. p < 0.0001 in b and c (ANOVA); *p < 0.05, **p < 0.01, and ****p < 0.0001 (Holm-Sidak’s post-hoc test). Scale bar: 10 μm in a

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