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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

Fig. 7

PRDX6 protein is exclusively expressed by astrocytes and absent in plaque-associated microglia. Representative LSCM images of mature plaques co-labeled with X-34 (fibrillar core), anti-PRDX6, and anti-GFAP antibodies in a, and with X-34, and anti-PRDX6, and anti-Iba1 antibodies in b evidencing colocalization of PRDX6 immunostaining with that of GFAP but not with Iba1. Co-labeling with anti-PRDX6, and anti-Iba1 antibodies in b reveals in fact two distinct cell populations localized further apart and closer to the fibrillar core, respectively. There is apparent APP/Prdx6Tg > APP/Prdx6+/+ > APP/Prdx6+/− gradient of PRDX6 immunostaining intensity across the genotypes. PRDX6 immunostaining does not co-localize with the X-34 labeled fibrillar plaque core. Scale bar: 10 μm in a and b

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