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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

Fig. 8

Prdx6 expression modulates plaque seeding. Shown are representative images of nascent plaques in female mice aged 6 months of indicated genotypes, which were co-labeled with X-34 (fibrillar core), and anti-Aβ (HJ3.4 clone) and anti-GFAP antibodies in a and with X-34, anti-Aβ (HJ3.4 clone), and anti-Iba1 antibodies in b evidencing an inverse relationship between Prdx6 expression level and the numerical density of nascent plaques and the numerical density of nascent plaques devoid of GFAP+ and Iba1+ cells. Quantitative analysis of nascent plaque numerical density in the brain cortex performed on X-34/Aβ/GFAP co-labeled sections in c, and on X-34/Aβ/Iba1 co-labeled sections in d. In this analysis nascent plaques were arbitrary defined as having no X-34+ core or having X-34+ core < 40 μm2. Black bars represent number of plaques devoid of GFAP+ or Iba1+ cells /mm2 and are superimposed on grey bars representing the total number of plaques /mm2 for a given genotype. Values in c and d represent mean (+SEM) from n = 6 female mice per genotype. p < 0.0001 in c and d (ANOVA); p < 0.01, p < 0.001, and p < 0.0001 denote significance for the density of GFAP and Iba1 devoid plaques across genotypes; *p < 0.05, and ***p < 0.001, denote significance for the density of all plaques (Holm-Sidak’s post-hoc test). Scale bar: 20 μm in a and b

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