TY - JOUR AU - Takalo, Mari AU - Wittrahm, Rebekka AU - Wefers, Benedikt AU - Parhizkar, Samira AU - Jokivarsi, Kimmo AU - Kuulasmaa, Teemu AU - Mäkinen, Petra AU - Martiskainen, Henna AU - Wurst, Wolfgang AU - Xiang, Xianyuan AU - Marttinen, Mikael AU - Poutiainen, Pekka AU - Haapasalo, Annakaisa AU - Hiltunen, Mikko AU - Haass, Christian PY - 2020 DA - 2020/09/11 TI - The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions JO - Molecular Neurodegeneration SP - 52 VL - 15 IS - 1 AB - Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare coding variant in the PLCG2 gene (rs72824905, p.P522R) expressed in myeloid lineage cells was recently identified and shown to reduce the risk for AD. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-020-00402-7 DO - 10.1186/s13024-020-00402-7 ID - Takalo2020 ER -