Skip to main content
Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

Fig. 3

Plcγ2-P522R expression increases microglia activation in the brain of one-year-old mice. a Representative PET-images of the uptake of 18F-FEPPA (time window 15-70 min) (upper panel) in the brains of Plcγ2-P522R homozygous knock-in (KI) and wild type (WT) female mice at 1 year of age. Estimated total distribution volume (DV, ml/ml) in total brain, frontal cortex, pons, hippocampus, and cerebellum calculated with the Logan model using image derived input function (IDIF, lower panel), n = 3–4 per genotype. Independent samples t-test, *p < 0.05. b Representative PET images of the uptake of 18F-FDG (time window 20-80 min) in WT and KI mouse (upper panel). Cerebral metabolic rate of glucose [MRGlu, (ml/min*ml)] was estimated using the Patlak model (with lumped constant of 0.71, lower panel), n = 3–4 per genotype. Independent samples t-test

Back to article page
\