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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Fig. 6

Tau mAbs inhibit seeded aggregation of tau pathology in slice cultures. a Quantification of immunofluorescent staining of hyperphosphorylated tau with AT8 antibody in hippocampal slice cultures treated with AD-tau and IgG control, SKT82, or DMR7. One-way ANOVA with Dunnett’s post-hoc test **p < 0.01, *p < 0.05, n = 6 comprised of three fields of view per slice for two independent hippocampal slices. b Representative images of AT8 immunofluorescent staining of tau pathology induced in the CA3 of hippocampal slices by treatment with AD-tau and inhibition by tau mAbs. c Confocal microscopy of the nuclear neuronal marker NeuN (red) with AD-tau induced tau aggregates stained with the phospho-tau antibody AT8 (green)

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Molecular Neurodegeneration

ISSN: 1750-1326