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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Fig. 8

Behavioral characterization of 7-month old 5xFAD mice 3 month post-AD-tau injection. a Open field measurements of total activity and b Y-maze spontaneous alternations showed no difference between PBS controls and AD-tau-injected mice with IgG control or tau mAb treatment. Analyzed by One-way ANOVA. c Contextual fear conditioning showed that 5xFAD mice learned well and demonstrate a conditioned freezing response upon training but no differences at 14-day remote recall. ***p < 0.001 analyzed by two-tailed paired t-test

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