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Table 1 Pharmacokinetics of tau mAb blood-brain barrier penetrance. ELISA assays of DMR7 and SKT82 levels in CSF and plasma of mice 4- and 7-days post-IP injection quantified in comparison to standard curves of purified DMR7 and SKT82

From: Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

  Dose (mg/kg) Days post injection Plasma (μM) Plasma
%CV
CSF (nM) CSF
%CV
CSF/ plasma ratio (%)
DMR7
n = 3
60 4 1.29 + 0.22 17 3.78 + 0.95 25 0.31 + 0.12
DMR7
n = 3
60 7 1.24 + 0.45 36 2.9 + 1.9 66 0.22 + 0.08
SKT82
n = 2
60 4 0.91 + 0.24 26 1.20 + 0.06 5 0.14 + 0.03
SKT82
n = 3
60 7 0.65 + 0.19 30 0.70 + 0.16 28 0.12 + 0.06
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