Fig. 2
From: Integrated analysis of the aging brain transcriptome and proteome in tauopathy
Examples of Tau-induced changes in the transcriptome and proteome. log2-transformed expression of selected genes in elav > TauR406W (Tau, red) and elav (Control, gray) is shown for transcriptome (depth normalized counts) and proteomes (normalized label-free quantification intensity (LFQ)). Genes were selected to be representative within our dataset and are all differentially expressed (FDR < 0.05) in both the transcriptome and proteome, based on the joint regression model including all longitudinal data and adjusting for age. CCT1 is only differentially-expressed at the protein level. AttA and CCT1 transcripts (bottom) are plotted on a different scale than the other examples due to the increased dynamic range of changes (for AttA). Additional example plots can be found in Additional file 1: Figure S8