Fig. 4From: Integrated analysis of the aging brain transcriptome and proteome in tauopathyModel for integrating Tau-induced gene expression changes and modifiers. Schematic diagram illustrating the relationship between Tau-induced perturbations in gene expression and potential impact on neurodegeneration. Tau may cause up- or down-regulation for a given gene of interest, and either change may amplify (red) or protect against (green) neurotoxicity. Recapitulating the observed gene expression change through experimental manipulations and observing the consequences for neurodegenerative phenotypes permits reconstruction of the causal chain. See Table 4 for specific examplesBack to article page