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Table 1 Tau-triggered differentially expressed genes

From: Integrated analysis of the aging brain transcriptome and proteome in tauopathy

  Day 1 Day 10 Day 20 Total
cross-sectional age-adjusted
TauWT 491 (54) 431 (143) 1096 (76) 1514 (213) 1653 (123)
TauR406W 3179 (97) 1616 (173) 4087 (581) 5494 (697) 4992 (503)
  1. Differentially-expressed transcripts (and proteins, in parentheses) are indicated based on cross-sectional comparisons in 1-, 10-, or 20-day-old elav > TauWT or elav > TauR406W animals and controls. Based on PCA analysis [31], the decrease in differentially expressed transcripts at day 10 in TauR406W flies is likely due to sample heterogeneity. The total number of unique differentially expressed transcripts/proteins from the cross-sectional analyses are also indicated, along with complementary results from the joint regression model including all longitudinal data and adjusting for age. Statistical analysis was based on a Wald test (FDR < 0.05). See Additional file 2: Tables S2 and S5 for complete results
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