| Day 1 | Day 10 | Day 20 | Total |
---|
cross-sectional | age-adjusted |
---|
TauWT | 491 (54) | 431 (143) | 1096 (76) | 1514 (213) | 1653 (123) |
TauR406W | 3179 (97) | 1616 (173) | 4087 (581) | 5494 (697) | 4992 (503) |
- Differentially-expressed transcripts (and proteins, in parentheses) are indicated based on cross-sectional comparisons in 1-, 10-, or 20-day-old elav > TauWT or elav > TauR406W animals and controls. Based on PCA analysis [31], the decrease in differentially expressed transcripts at day 10 in TauR406W flies is likely due to sample heterogeneity. The total number of unique differentially expressed transcripts/proteins from the cross-sectional analyses are also indicated, along with complementary results from the joint regression model including all longitudinal data and adjusting for age. Statistical analysis was based on a Wald test (FDR < 0.05). See Additional file 2: Tables S2 and S5 for complete results