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Table 4 Integration of gene expression with genetic modifiers

From: Integrated analysis of the aging brain transcriptome and proteome in tauopathy

Drosophila Human
Gene Amplifying vs. Protective AD Tangles
up-regulated
cher A   
Uba1 A   
Myd88 A MYD88  
CG10889 A ZC3H12C  
CG7970 A   
Elf A GSPT1 EIF2S1
Fs(2)Ket A   
Mekk1 A   
Nrg A CHL1 NRCAM
smid A   
Diap1 A BIRC3  
wun A PLPP1  
Stip1 P STIP1  
RpS21 P RPS21  
Past1 P EHD2  
Tis11 P ZFP36L1, ZFP36L2  
w P   
Gbs-70E P PPP1R3C  
cher P   
dally P   
down-regulated
fry A   FRYL
Ptp4E A   
Atg6 A   
Fmr1 A   
mub A   
Bacc A   
jing P   AEBP2
E(bx) P   BPTF
tou P   BAZ2B
jar P   
Mi-2 P CHD5, CHD4 CHD4
sgg P   
milt P   TRAK2
stg P CDC25B CDC25B
twe P CDC25B CDC25B
Atx2 P   ATXN2L
CG7231 P   
  1. All Drosophila genes listed (at left) are modifiers of Tau-mediated neurodegeneration based on published unbiased screens [23,24,25]. Direction of Tau-induced differential expression is noted, including up- (top) or down-regulation (bottom) of transcripts. Based on the results of modifier tests, we can infer whether the observed Tau-induced expression perturbation is amplifying (A) or protective (P) for Tau neurotoxicity. See also Fig. 4 and Additional file 2: Table S9 and S10. For each fly gene, we also note whether human gene homolog(s) are differentially expressed in human postmortem brain tissue from published analyses of AD [10] and neurofibrillary tangle burden [11]. In cases where the direction of expression was concordant with Drosophila, the human gene name is indicated in boldface. In a smaller PSP dataset [9], only 1 fly gene, mub, had a differentially-expressed human homolog, PCBP4
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