Integrated analysis of the aging brain transcriptome and proteome in tauopathy

Table 4 Integration of gene expression with genetic modifiers

All Drosophila genes listed (at left) are modifiers of Tau-mediated neurodegeneration based on published unbiased screens [23,24,25]. Direction of Tau-induced differential expression is noted, including up- (top) or down-regulation (bottom) of transcripts. Based on the results of modifier tests, we can infer whether the observed Tau-induced expression perturbation is amplifying (A) or protective (P) for Tau neurotoxicity. See also Fig. 4 and Additional file 2: Table S9 and S10. For each fly gene, we also note whether human gene homolog(s) are differentially expressed in human postmortem brain tissue from published analyses of AD [10] and neurofibrillary tangle burden [11]. In cases where the direction of expression was concordant with Drosophila, the human gene name is indicated in boldface. In a smaller PSP dataset [9], only 1 fly gene, mub, had a differentially-expressed human homolog, PCBP4

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