Skip to main content
Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

Fig. 3

Oligodendrocyte/Myelin impairments in adult Trem2Y38C/Y38C and Trem2−/− mice. a-c Mbp, Mobp and Olig2 transcript levels were determined by quantitative-PCR. a Mbp transcripts were reduced in both Trem2Y38C/Y38C and Trem2−/− cortical lysates and b-c Mobp and Olig2 mRNA reduced significantly in Trem2−/− cortical lysates. d Western blot analysis and e Quantification of myelin proteins CNPase and MBP. CNPase levels were reduced significantly in Trem2−/− mice and Mbp levels were significantly reduced in both Trem2Y38C/Y38C and Trem2−/− mice. a-e Data represented as mean ± SEM. N = 4 (2 males, 2 females); One-way ANOVA with Tukey’s post hoc test; *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page
\