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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

Fig. 5

Hippocampal synaptic plasticity is reduced in Trem2Y38C/Y38C and Trem2−/− mice. a Input-output curves were similar in Trem2Y38C/Y38C, Trem2−/−, and WT mice. b,c Hippocampal Schaffer collateral-CA1 LTP is significantly reduced in Trem2Y38C/Y38C (green) and Trem2−/− (red) mice as compared to WT mice (black) at 6 months of age. b Superimposed representative traces before (black) and 60 min after high-frequency stimulation (gray) in each genotype. c Mean time course of fEPSP slope in hippocampal slices from WT (black), Trem2Y38C/Y38C (green) and Trem2−/− (red). Arrow indicates time of high frequency stimulation. d Average of normalized fEPSP slope for final 10 min of recording (60–70 min) relative to 10-min baseline average (dotted line). Data are shown as mean ± SEM. Sample sizes: WT mice, N = 15 (7 females and 8 males, n = 33 recordings); Trem2Y38C/Y38C mice, N = 7 (3 females and 4 males, n = 20 recordings); Trem2−/− mice, N = 8 (4 males and 4 females, n = 15 recordings). One-way ANOVA with Tukey’s post hoc test. ***P < 0.001, **** P < 0.0001

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