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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease

Fig. 6

Time-dependent impairment of nucleocytoplasmic transport activity in hiBFCNs. a A schematic of the reporter system for analyzing NCT activity. b Quantification of subcellular distributions of the reporters at 28 dpi. Each point represents a single cell (mean ± SEM; n = 124 for NL from 4 samples; n = 145 for AD from 4 samples; ns, not significant). c Quantification of subcellular distributions of the reporters at 51 dpi. Each point represents a single cell (mean ± SEM; n = 92 for NL from 3 samples; n = 127 for AD from 4 samples; *p = 0.0309, **p = 0.0067, and ****p < 0.0001). d Representative confocal images of reporter subcellular distributions in hiBFCNs at 51 dpi. Cell soma and nucleus are outlined. Scale bar, 10 μm

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