Fig. 2
From: A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Human to mouse comparison and probe coverage summary statistics. a Human-mouse sequence divergence (median dN/dS values) is inversely correlated (Pearson’s correlation coefficient: − 0.96) with the fraction of genes being expressed in B6 mouse brain for each of the human co-expression modules. b Coverage of the 770 selected mouse NanoString probes for the 30 human co-expression modules associated with five functional consensus clusters. The size and number of human co-expression modules differs for the three post-mortem brain cohorts (ROSMAP, Mayo, Mount Sinai Brain Bank) and across the seven included brain regions. c This results in a varying degree of probe coverage for each module with a number of disease associated consensus clusters (a-e), reflecting disease related pathways and processes