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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

Fig. 3

NanoString Mouse AD probe genes are strongly conserved and show high expression levels in the mouse brain. Comparison between gene-level sequence divergence and transcript abundances in 6 months old B6 mouse brains for all genes (red) in human co-expression modules and the subset of 770 genes covered by NanoString probes on the Mouse AD panel (green). Human transcripts within AMP-AD co-expression modules targeted by selected mouse NanoString probes highlighted in green showed higher levels of sequence conservation and transcript abundance across species when compared to unselected genes within modules

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Molecular Neurodegeneration

ISSN: 1750-1326