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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

Fig. 4

Time-course correlation analysis between the 5xFAD mouse model and 30 human co-expression modules using the NanoString Mouse AD panel. a The 5xFAD mouse model shows a significant correlation with functionally distinct AMP-AD co-expression modules that correspond to previously reported phenotypes from by Oakley et al. [15] and Landel et al. [16]. Circles correspond to significant (p < 0.05) positive (blue) and negative (red) Pearson’s correlation coefficients for gene expression changes in 5xFAD mice (log fold change of strain minus age matched B6 mice) and human disease (log fold change for cases minus controls). Correlations are based on the comparison of mouse NanoString data to human RNA-seq expression data from the three AMP-AD cohorts for seven brain regions. Human co-expression modules are ordered into Consensus Clusters A-E [9] describing major sources of AD-related alterations in transcriptional states across independent studies and brain regions. Consensus clusters are annotated based on the most significantly enriched and non-redundant Reactome pathway terms (Supplemental Tables S1, S2). b Reactome pathway enrichment analysis for multiple time points (1 month to 12 months) implicates multiple immune and stress-related processes in the response to amyloid deposition in the course of aging within the 5xFAD mouse model

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