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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Fig. 2

APOE*ε2 protects against AD. a Age-stratified odds ratio for AD risk (with APOE*ε3/3 as reference group) in individuals of different APOE genotypes. APOE*ε2/2 and APOE*ε2/3 individuals have reduced risk of AD (OR < 1) compared to APOE*ε3/3 individuals and the protective effect sizes are similar in different age groups. In contrast, APOE*ε4 carriers and APOE*ε2/4 individuals, have increased risk of AD (OR > 1) and the effect size varies among different age groups. b Kaplan-Meier curves showing the percentage of pathologically confirmed AD cases in individuals of different APOE genotypes. APOE*ε2 carriers are less likely to be pathologically diagnosed as AD. The protective effect is more prominent in APOE*ε2/2 homozygotes. a A reproduction of published data by Genin, et al., Mol Psychiatry. 2011 Sep;16(9):903-7, with permission. b A visual adaptation of a figure from Reiman et al., Nat Commun. 2020 Feb 3;11(1):667, with permission

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