Fig. 5
From: Astrocyte-derived clusterin suppresses amyloid formation in vivo
CLU haploinsufficiency results in augmented gliosis. a Astrogliosis (red) is more abundant around amyloid aggregates (blue) in APP/PS1; Clu+/− mice compared to controls. Scale bar, 100 μm. b Quantification of GFAP intensity in brain sections of APP/PS1; Clu+/+ (100 ± 17.25) compared to APP/PS1; Clu+/− mice (231.1 ± 51.71). N = 7–8 mice/group. Data are presented as mean ± S.E.M. and analyzed by Student’s t test *p < 0.05. c Relative expression of Gfap levels in cortex of APP/PS1; Clu+/+ (1 ± 0.11) and APP/PS1; Clu+/− mice (1.44 ± 0.17). N = 8 mice/group. Data are presented as mean ± S.E.M. and analyzed by Student’s t test *p < 0.05. d Microgliosis (red) marked by IBA1 is associated with amyloid plaques (blue). Scale bar, 100 μm. e Quantification of IBA1 intensity in brain sections of APP/PS1 mice showing higher levels of microgliosis in APP/PS1; Clu+/− mice (138.2 ± 9.83) compared to APP/PS1; Clu+/+ mice (100 ± 14.81). N = 7–8 mice/group. Data are presented as mean ± S.E.M. and analyzed by Student’s t test *p < 0.05. f Expression levels of Cst7 in cortex of APP/PS1; Clu+/+ (1 ± 0.16) and APP/PS1; Clu+/− (1.11 ± 0.19) mice. N = 8 mice/group. Data are presented as mean ± S.E.M. and analyzed by Student’s t test