TY - JOUR AU - Kumar, Sunny AU - Phaneuf, Daniel AU - Cordeau, Pierre AU - Boutej, Hejer AU - Kriz, Jasna AU - Julien, Jean-Pierre PY - 2021 DA - 2021/01/07 TI - Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD JO - Molecular Neurodegeneration SP - 1 VL - 16 IS - 1 AB - TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases. In addition, the impact of TDP-43 proteinopathy on neuronal translational profile also remains unknown. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-020-00420-5 DO - 10.1186/s13024-020-00420-5 ID - Kumar2021 ER -