Fig. 3

IMS-088 improved cognitive performance of transgenic mice expressing hTDP-43 mutants. Passive avoidance test at 12 months of age in (a) hTDP-43^G348C mice (vehicle vs IMS-088 treated groups) (b) hTDP-43^A315T mice (vehicle vs IMS-088 treated groups). Graphs show freezing time in second spent by mice. Novel object recognition test at 12 months of age in (c) hTDP-43^G348C mice (vehicle vs IMS-088 treated groups) (d) hTDP-43^A315T mice (vehicle vs IMS-088 treated groups). Graphs show percentage of time spent with novel objects, 1-way ANOVA with Bonferroni’s multiple comparison test as the post-test ** p < 0.01 and * p < 0.05