Skip to main content
Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

Fig. 5

IMS-088 treatment reduced cytoplasmic TDP-43 aggregates in mutant hTDP-43 mice. a Representative pictures showing TDP-43 (red), NeuN (green) and DAPI (blue) in brain sections of vehicle and IMS-088 treated hTDP-43 mutant transgenic mice. b Representative immunoblots and quantification of RIPA insoluble and RIPA soluble fractions of brain from n = 3–4 independent mice from both hTDP-43G348C and hTDP-43A315T mice. The TDP-43 was normalized with ponceau or GAPD H. c Representative images and graph showing the cytoplasmic hTDP-43 in spinal motor neurons by IMS-088 treatment and the quantification of cytoplasmic to nuclear ration of hTDP-43 in hTDP-43G348C mice (n = 75 neurons from 3 mice each group. Statistical analysis used was unpaired T-test. Data represents mean ± sem. ** p < 0.01; *** p < 0.001

Back to article page