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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

Fig. 6

IMS-088 treatment boosted autophagy. a Representative immunoblots showing autophagic markers in the brain of hTDP-43A315T mice received vehicle or IMS-088 treatment. Data Showing normalized density of (b) p62 (c) Beclin-1(d) ATG 5 (e) LC-3IIB in hTDP-43 mutant mice received either saline or IMS-088 (n = 3–4). Protein levels were normalized using Actin. Statistical analysis used was unpaired T-test. Data represents mean ± sem. ** p < 0.01

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Molecular Neurodegeneration

ISSN: 1750-1326