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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

Fig. 7

Translational suppression of neurofilament mRNAs in hTDP-43A315T mice. a Volcano plot of Affymetrix 2.0 ST chip results of mRNA isolated from brain neuronal ribosome complex of NFL-rRFP and NFL-rRFP;hTDP-43A315T mice at 12 months of age. Experiments were conducted in three biological replicates (n = 6 mice/condition). b Volcano plot of proteomic results of peptide isolated from brain neuronal ribosomal complex of NFL-rRFP and NFL-rRFP;hTDP-43A315T mice analyzed with the mass spectroscopic methods at 12 months of age. Experiments were conducted in three biological replicates (n = 6 mice/condition). c GO functional analysis of isolated peptide from brain neurons of NFL-rRFP;hTDP-43A315T mice revealed neuronal cytoskeletal deregulation. Data showing levels of ribosome-bound (d) mRNAs and (e) peptides for cytoskeletal proteins Nefl, Nefm and α-internexin in NFL-rRFP and NFL-rRFP;hTDP-43A315T mice at 12 months of age. Data represents mean ± sem. ** p < 0.01

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Molecular Neurodegeneration

ISSN: 1750-1326