Fig. 1
From: Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline
Timeline of experimental protocol. pMCAo: permanent middle cerebral artery occlusion; IP: intraperitoneal; n: number of mice/group. Long term potentiation, neuronal death and microglia/macrophage densities were studied in both hippocampus; white matter density and microglia/macrophages density were studied in both striatums; microglia/macrophage density was studied in the peri-infarct and contralateral homonymous area. Indoleamine 2, 3 dioxygenase (IDO) activity that converts Tryptophan (TRP) to Kynurenine (KYN), and kynurenine metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA) were measured in serum and brain at D40. Four groups were evaluated for each time point: control mice (C), diabetic mice (D), pMCAo mice (mice subjected to permanent middle cerebral artery occlusion without diabetes) and pMCAo + D (mice subjected to permanent middle cerebral artery occlusion with diabetes); n is the number of mice/group