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Fig. 11 | Molecular Neurodegeneration

Fig. 11

From: Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline

Fig. 11

Serum changes of the tryptophane (TRP) (a) and kynurenine (KYN) (b) concentrations, indoleamine 2, 3-dioxygenase (IDO) activity (c), kynurenic acid (KYNA) (d) and quinolinic acid (QUIN) (e) concentrations and QUIN/KYNA ratios (f) in patients without (C-) or with (C+) cognitive decline. There were no significant differences in serum TRP (a) or KYNA concentrations (d) between patients. Serum levels of KYN (b) (P < 0.01), IDO enzymatic activity (c) (P < 0.01), QUIN (e) (P < 0.001), and QUIN/KYNA (f) (P < 0.0001) were significantly elevated in the C+ group compared to the C- group. **P < 0.01, ***P < 0.001, ****P < 0.0001

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