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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline

Fig. 4

Effects of pMCAo and diabetes on long-term potentiation (LTP) of CA1 field Excitatory Post-Synaptic Potentials (fEPSP) induced in hippocampal slices by tetanic stimulation of Schaffer collaterals. Graphs show fEPSP amplitudes (μV) before (pre) and after (post) tetanic stimulation in (a) control, (b) diabetic, (c, d) pMCAo and (e, f) pMCAo+D mice. LTP was assessed for both pMCAo and pMCAo+D mice in hippocampus ipsilateral (c, e) or contralateral (d, f) to the infarct. Significant synaptic LTP was detected in slices from control (P < 0.001) and diabetic mice (P < 0.05). LTP was not induced in either ipsi- or contralateral slices from both pMCAo and pMCAo+D mice. fEPSP, field excitatory post synaptic potential. *P < 0.05, ***P < 0.001

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