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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline

Fig. 6

Serum and brain changes of the tryptophan (TRP) and kynurenine (KYN) concentrations and indoleamine 2, 3-dioxygenase (IDO) activity in pMCAo+D mice. These elements of the tryptophan/kynurenine pathway are shown at the left. a-f show changes in concentrations or activity of these molecules in the C, D, pMCAo and pMCAo+D mice, in serum (a, b, c) and brain (d, e, f). a Serum TRP levels did not differ between the four groups. b Serum KYN levels were significantly higher in D than in C mice (P < 0.05). c Serum IDO activity was significantly higher in pMCAo+D animals than in pMCAo mice (P < 0.01) or C mice (P < 0.0001). It was higher in D mice than in pMCAo (P < 0.01) or C mice (P < 0.0001). d Brain TRP levels did not differ between the four groups. e Brain KYN levels were significantly higher in pMCAo+D animals than in pMCAo or C mice (P < 0.0001). They were higher in D mice than in pMCAo or C mice (P < 0.0001). f Brain IDO activity was significantly higher in pMCAo+D animals than in pMCAo mice (P < 0.01) or C mice (P < 0.01). It was higher in D mice than in pMCAo (P < 0.0001) or C mice (P < 0.001) (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

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