Fig. 7

Serum and brain changes of the kynurenic acid (KYNA) and quinolinic acid (QUIN) concentrations and QUIN/KYNA ratio in pMCAo+D mice. These elements of the tryptophan/kynurenine pathway are shown at the left. a-f show changes in concentrations or activity of these molecules in the C, D, pMCAo and pMCAo+D mice, in serum (a, b, c) and brain (d, e, f). a Serum KYNA concentrations were lower in pMCAo+D mice than in D or C mice (P < 0.0001). KYNA levels were lower in pMCAo mice than in D and C mice (P < 0.0001) and lower in C mice than in D mice (P < 0.0001). b Serum QUIN levels were significantly higher in pMCAo+D than in C mice (P < 0.0001), D (P < 0.0001) or in pMCAo mice (P < 0.05). They were higher in pMCAo mice than in C or D mice (P < 0.0001). c The serum QUIN/KYNA ratio was higher in pMCAo+D mice than in all other groups (P < 0.0001). The ratio was significantly higher in pMCAo mice than in D or C mice (P < 0.0001). d Brain KYNA concentrations were lower in pMCAo+D mice than in D (P < 0.0001) or in C mice (P < 0.05). Brain KYNA levels were lower in pMCAo mice than in D (P < 0.0001) and lower in C mice than in D mice (P < 0.0001) (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). e Brain QUIN levels were significantly higher in pMCAo+D than in C mice (P < 0.0001), D (P < 0.0001) or in pMCAo mice (P < 0.001). They were higher in pMCAo mice than in C or D mice (P < 0.0001). f The brain QUIN/KYNA ratio was higher in pMCAo+D mice than in all other groups (P < 0.0001). The ratio was significantly higher in pMCAo mice than in D (P < 0.0001) or C mice (P < 0.01)