Fig. 8

Neuronal degeneration in the ipsi- and contralateral hippocampus in C, D, pMCAo and pMCAo+D mice. Fluorojade staining was used to label degenerating cells in both hippocampus at D40. a Fluorojade staining of ipsilateral hippocampus in pMCAo+D mice (× 20 and magnification × 40). The diagram above shows the distant and restricted site of the induced infarct. b Numbers of Fluorojade+ neurons in ipsilateral hippocampus were significantly greater in pMCAo+D mice than in C (P < 0.0001) or D mice (P < 0.001). Neuronal degeneration was higher in pMCAo mice than in C or D mice (P < 0.01). c In contralateral hippocampus, numbers of degenerating neurons were higher in pMCAo+D mice than in C (P < 0.001) or D mice (P < 0.01). Numbers of Fluorojade+ neurons were significantly higher in pMCAo mice than in C mice (P < 0.05). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001