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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

Fig. 5

C3aR1 knock-out abolishes TLQP-21 induced DEGs. a, b, Volcano plot representations of the DEGs in WT or C3aR1 KO (KO) primary microglia, treated with vehicle, TLQP-21, or C3aSA. Only DEGs with FDR < 0.05 were represented (red dots). c, Correlation of fold changes in DEGs between KO vs WT and KO + TLQP-21 vs WT, KO vs WT and KO + C3aSA vs WT, KO + TLQP-21 vs WT and KO + C3aSA vs WT, respectively. d, Network modules identified by weighted gene co-expression network analysis (WGCNA). The co-expression network (20 samples in total) was constructed using all WT and KO-related comparisons. e, Sunburst representation of Gene Ontology (GO) analysis enriched in the “brown” module. f, Selected canonical pathways analysis (using Ingenuity Pathway Analysis (IPA) software) predicted to be increased (red) or decreased (blue) in the KO microglia compared to WT (full list in Additional file 2: Table S2)

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