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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

Fig. 2

A schematic to illustrate the various targets for APOE-based AD therapeutics. See the main text for details. Black arrows pointing to the red text boxes indicate a mode of intervention while blue arrows indicate the movement of the drug or protein. Black solid arrows crossing the BBB show permeability while black dashed arrows show BBB semi-permeability. ABCA1: ATP-binding cassette transporter A1; LDLR: low density lipoprotein receptor; APOE: apolipoprotein E; Aβ: amyloid-β; TREM2: triggering receptor expressed on myeloid cells 2

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