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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers

Fig. 1

Methylation of C9orf72 promoter. a Increased methylation levels of the C9orf72 promoter are observed when comparing patients with a C9orf72 repeat expansion (C9Plus) to patients without this expansion (C9Minus) or to control subjects (Control). The median is represented by a solid black line, and each box spans the interquartile range (IQR; 25th percentile to 75th percentile). b Methylation levels appear to be fairly stable over time: subjects with high methylation levels remain high, while those with low levels remain low. For each individual, longitudinal measurements are connected by a solid colored line. c In blood, frontal cortex, and cerebellum, a similar methylation pattern is seen. For each individual, three bars are displayed that correspond to methylation levels in a specific tissue type

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