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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers

Fig. 2

Expression of C9orf72 transcripts. a In patients with an expanded C9orf72 repeat (C9Plus), the expression levels of total C9orf72 transcripts are lower than in patients without this expansion (C9Minus) or in control subjects (Control). The median is represented by a solid black line, and each box spans the interquartile range (IQR; 25th percentile to 75th percentile). b Over time, the levels of total C9orf72 transcripts remain relatively stable. One outlier is detected with levels that are consistently higher than in other C9orf72 expansion carriers. This outlier has an expansion of 7.9 kb (~ 900 repeats) in addition to an expansion of 3.4 kb (~ 200 repeats). For each individual, longitudinal measurements are connected by a solid colored line

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Molecular Neurodegeneration

ISSN: 1750-1326