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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease

Fig. 2

Disease subtype-specific interactors bound to high-density prion protein oligomers. A) The experimental setup for carrying out the co-immunoprecipitation of HDPs and their potential interactors. B) Numerical Venn-diagram showing the overlap of subtype-specific HDP interactors. pF12-pF17: pools of high-density fractions 12–17 from multiple patient samples. IP-F-Con: high-density PrP (HDP) interactors in control HDFs pools from 12 to 17 (collectively), IP-F-spAD: HDP interactors in spAD HDFs pools from 12 to 17, IP-F-rpAD: HDP interactors in rpAD HDFs pools from 12 to 17, IP-F-MM1: HDP interactors in sCJD-MM1 HDFs pools from 12 to 17, IP-F-VV2: HDP interactors in sCJD-VV2 HDFs pools from 12 to 17, IP-F-MM2: HDP interactors in sCJD-MM2 HDFs pools from 12 to 17

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