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Table 1 HDP-binding interactors in rpAD high-density fractions identified by mass spectrometry assisted co-immunoprecipitation using anti-PrP antibody

From: Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease

No. IDs UniProt Acc. No. Protein name Occurrence Sub-cellular location Disease Relevance
1 KCC2B Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta rpAD-F12,
sCJD-MM1-F13, 17, sCJD-MM2-F16, 17, sCJD-VV2-F16, 17
C, Ck, Ce, Sr, Sy Alzheimer’s disease [59]
2 KCC2D Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta rpAD-F12,
sCJD-MM1-F13, 17, sCJD-MM2-F16, 17, sCJD-VV2-F16, 17
Cm, Sl
3 EPDR1 Q9UM22 Mammalian ependymin-related protein 1 rpAD-F12,
sCJD-MM1-F13–16, sCJD-MM2-F13–16, sCJD-VV2-F12, 14, 15
S Unknown
4 DIRA2 Q96HU8 GTP-binding protein Di-Ras2 rpAD-F13, 15,
sCJD-VV2-F17
Cm Unknown
5 G2L2 Q8NHY3 GAS2-like protein 2 rpAD-F16 C, Ck Unknown
6 1433S P31947 14–3-3 protein sigma rpAD-F17,
sCJD-VV2-F17
C, Nu, S Parkinson’s disease [60], Alzheimer’s disease, Creutzfeldt Jakob disease [61], Epilepsy [62]
  1. F12 to F17: HDF-pool 12 to 17. Ce: centrosome, Sy: synapse, Sr: sarcoplasmic reticulum, C: cytoplasm, Ck: cytoskeleton, Nu: nucleus, S: secreted, Cm: cell membrane, Sl: sarcolemma, The localization of proteins and accession number are assigned as in the ExPASy protein database and Uniprot data base, respectively. Disease relevance of the HDP-interacting proteins was identified using Uniprot database search, as well
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