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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry

Fig. 3

Altered metabolic profiles in drug-naïve PD compared with HC. a PLS-DA score plot of DN-PD and HC in cohort 1. R2X = 0.212, R2Y = 0.758, Q2 = 0.594. The analysis of variance was based on cross-validated prediction residuals (CV-ANOVA) data: p = 9.6139E-014, F factor = 26.7611. b Volcano plot of the differential metabolites in DN-PD filtered by univariate analysis. c Venn plot of the differential metabolites filtered by PLS-DA model and univariate analysis. d Heat map of the 50 differential metabolites in DN-PD. Blue indicates a decreased level, orange indicates an increased level. e Associations of metabolites with disease severity, duration time and age. DT: duration time; IAA: indolelactic acid; Ald: aldosterone; Pan: pantothenic acid; AceMet: N-acetyl-L-methionine

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