Fig. 5
From: Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry
Differential metabolites in PD compared with HC and NDC. a OPLS-DA score plot of PD, HC and NDC in cohort 3. R2X = 0.389, R2Y = 0.543, Q2 = 0.347. CV-ANOVA data: p = 0, F factor = 17.7056. b ~ e Box plots of FFA 10:0, FFA 12:0, indolelactic acid and phenylacetyl-L-glutamine in three groups. Data were expressed as means ± SE. *: p < 0.05, **: p < 0.01, ***: p < 0.001. The ROC curves of the metabolite panel to discriminate PD from control groups. f DN-PD vs. HC in cohort 1. The ranges of AUC values at the 95% confidence interval (CI) for FFA 10:0, FFA 12:0, indolelactic acid, phenylacetyl-L-glutamine and metabolite panel were 0.584 ~ 0.820, 0.534 ~ 0.776, 0.547 ~ 0.787, 0.585 ~ 0.816 and 0.742 ~ 0.922, respectively. g PD vs. HC in cohort 2. The AUC value ranges from 0.704 to 0.898 at 95% CI. h PD vs. HC in cohort 3. The AUC value ranges from 0.778 to 0.889 at 95% CI. i. PD vs. (HC + NDC) in cohort 3. The AUC value ranges from 0.711 to 0.822 at 95% CI