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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

Fig. 5

Astrocytic Clu overexpression promotes excitatory synaptic transmission in vivo. a Western blotting of Clu expression in hippocampal tissues of wild-type mice injected with AAV-GFAP-GFP or AAV-GFAP-Clu. Tubulin (Tub) was used as a loading control. b mEPSC sample traces from hippocampal CA1 pyramidal neurons of GFP or Clu transduced mice (scale bar, 20 pA/1 s). c Cumulative distribution of inter-event interval from all mEPSCs events of 14 neurons in mice injected with AAV-GFAP-GFP and 13 neurons injected with AAV-GFAP-Clu (left) and average mEPSC frequency (right). d Cumulative distribution of amplitude (left) and average mEPSC amplitude (right) of neurons infected with GFP (n = 14) or Clu (n = 13) viruses. Number of animals tested: N = 3 per group. Data presented are mean ± SEM. *p < 0.05 (Student’s t test)

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Molecular Neurodegeneration

ISSN: 1750-1326