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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

Fig. 8

Astrocytic Clu expression rescues synaptic dysfunction in 5xFAD mice. a mEPSC sample traces from hippocampal CA1 pyramidal neurons of WT and 5xFAD mice injected with AAV-GFAP-GFP or AAV-GFAP-Clu (scale bar, 20 pA/1 s). b Cumulative distribution of inter-event interval from all mEPSCs events (left) and average mEPSC frequency (right) (n = 12 WT; GFP; n = 15 WT; Clu; n = 11 5xFAD; GFP; n = 14 5xFAD; Clu). c Cumulative distribution of amplitude (left) and average mEPSC amplitude (right) (n = 12 WT; GFP; n = 15 WT; Clu; n = 11 5xFAD; GFP; n = 14 5xFAD; Clu). Number of animals tested: N = 3 per group. Data presented are mean ± SEM. *p < 0.05; n.s. not significant (p > 0.05) (Two-way ANOVA)

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