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Fig. 9 | Molecular Neurodegeneration

Fig. 9

From: Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy

Fig. 9

The effect of microglia from Socs3fl/fl and DKO mice on photoreceptor survival in retinal explant cultures. Brain microglia were cultured from Socs3fl/fl and DKO mice. Retinal explants were from Socs3fl/fl mice. Retinal explants were co-cultured with different types of microglia for 24 h. The flatmounts of retinal explants were then stained for cone arrestin and imaged by Dmi8 fluorescence microscopy. a Schematic diagram showing study design. b Representative images showing cone arrestin+ cells in retinal explants in different treatment groups. c Quantitative data of cone arrestin+ cells in different groups. The number of cone arrestin+ cells in different treatment groups was compared to retinal explants without microglia co-culture. Mean ± SD. N = 3 ~ 6 explants. * P < 0.05, ** P < 0.01, *** P < 0.001. Two-way ANOVA followed by Tukey’s multiple comparisons. Scale bar: 50 μm

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