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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

Fig. 4

Transcriptomic analysis of C9ORF72RE cortical neurons. a Principal component analysis of gene expression derived from RNA sequencing from C9ORF72RE cortical neurons (C9–1, C9–2; black) and isogenic gene-corrected control cortical neurons (C9–1Δ, C9–2Δ; red). Each data point represents a de novo differentiation of cortical neurons. As highlighted, the isogenic controls cluster accordingly with their respective parental C9ORF72RE lines. b Scatter plot showing comparison of gene expression (as average Fragments Per Kilobase of transcript per Million mapped reads) from cortical neurons derived from two independent C9ORF72RE iPSC lines and their corresponding isogenic controls. Green and orange data points denote the overlap of significantly up- and down-regulated genes in both mutant-correction pairs, respectively (false discovery rate, p < 0.2). c Selected gene ontology terms enriched in dysregulated genes

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