Fig. 10

Schematic illustration of the neural mechanism underlying aberrant gamma oscillation. APP/PS1 mice exhibit a reduction in both the number of OSNs and in EOG amplitude (Fig. 5), resulting in a decreased OE → OB glutamatergic innervation (Fig. 3c, Fig. 4i-j) and subsequent reduction in the capacity of M/T cells to trigger GC and other interneurons to release GABA, accompanied with a compensatory increase in GABA_AR subunits (Fig. 3d-i) that resulted in increased amplitude of inhibitory responses (Fig. 3b, Fig. 4f-g and n). Together, these alterations lead to reduction of E/I (Fig. 4o) and subsequent increase in gamma oscillation