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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Fig. 7

Inflammatory responses in primary astrocytes, mouse, and human cortex with different APOE genotypes. a, mRNA levels of proinflammatory markers in the primary astrocyte from ApoE3-TR or ApoE4-TR mice. b, mRNA levels of proinflammatory cytokines in the cortex of ApoE3-TR or ApoE4-TR mice. c, GFAP, and Iba1 expression in the cortex of ApoE3-TR or ApoE4-TR mice. (n = 5, 3 males and 2 females for b and c). d, mRNA levels of proinflammatory markers in inferior frontal cortex from AD patients. e, GFAP and Iba1 expression in inferior frontal cortex from AD patients. (n = 12 (F5/M7) for AD E3/E3; n = 10 (F6/M4) for AD E3/E4)

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