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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

Fig. 2

Striatal dopamine levels and intestinal synuclein aggregates in A30P and wild type (WT) control mice. (a) The amount of dopamine in the striatum of 2- and 12–13-month-old A30P and WT mice was determined by an enzyme-linked immunosorbent assay (ELISA). In the younger group (2 months) no changes were found in the striatal dopamine content, while the older A30P group exhibited significantly lower dopamine levels compared with their age-matched controls mice. WT animals are shown in blue, A30P mice in red. Quantitative data are expressed by means ± SD from segments of n = 6 for 2-month-old and n = 4 for 12–13-month-old PD and WT mice. ** p < 0,01 vs. wild type and control respectively by Student’s t test and Cohen’s d (Supplementary Fig. 7a); ns = not significant. Detection of overexpressed aggregated human α-synuclein (hu-synuclein) in the gut of 2-month-old mice revealed that there were no aggregates present in both intestines of the WT mice (b, d), while several aggregates were found in the small (c) and the large intestine (e) of the A30P mice. For synuclein detection n = 5 for A30P and WT were investigated

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