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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Fig. 1

PLX5622 treatment ablates microglia and increases amyloid plaque burden. a. Schematic of study design with PLX5622 administration. The table displays the number of mice used per experimental group. b. Representative images of IBA1 staining in the cortical region from WT and AppNL-G-F mice administered with control (CTRL) or PLX5622 chow. c. Unbiased quantification of percentage IBA1+ area in the cortex. d. Representative images of Thioflavin-S staining in the cortex. e. Unbiased quantification of plaque characteristics in Thioflavin-S stained slices in the cortex. f. Representative images of 4G8 staining in the cortex. g. Unbiased quantification of plaque characteristics in 4G8 stained slices in the cortex. h. Representative images of 82E1 staining in the cortex. i. Unbiased quantification of the plaque characteristics in 82E1 stained slices in the cortex. Representative images displayed in a-i are a mix of male and female mice. All values displayed in a-i represent the mean ± standard error (SEM) for a minimum of 6 animals per group. Graphs comparing values across all 4 groups were analyzed via 2-way analysis of variance (ANOVA) with Tukey post-hoc analysis for individual comparisons. Graphs comparing two groups were analyzed via Unpaired t-test. *p < 0.05, ** p < 0.01, *** p < 0.001, between indicated groups. #### p < 0.0001 for the PLX5622 factor

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