Fig. 2

Aβ deposition accelerates tau propagation in a microglia-dependent manner, while microglial depletion enhances NP tau formation. a. Schematic of injection coordinate and tri-synaptic pathway. b. Representative images of AT8 staining in the MEC and the GCL region of the DG. c. Unbiased quantification of AT8⁺ cell propagation from the MEC to the GCL. Tau propagation values across all 4 treatment groups are displayed. d. Representative image of plaques in the MEC of non-injected App^NL-G-F mice, injected mice receiving control chow, and injected mice receiving PLX5622. e. Unbiased quantification of percentage AT8⁺ plaque area within the MEC. Representative images displayed in a-e are a mix of male and female mice. All values displayed in a-e represent the mean ± SEM. Graphs comparing values across 4 groups were analyzed via 2-way ANOVA with Tukey post-hoc analysis for individual comparisons. Graphs comparing values across 3 groups were analyzed via 1-way ANOVA with Fisher’s LSD post-hoc analysis for individual comparisons. ^* p < 0.05, ^** p < 0.01 between indicated groups