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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

Fig. 6

Decreased correlation between promoter H3K27 acetylation state and gene expression in PD Pearson’s correlation between the adjusted promoter H3K27ac counts and the adjusted RNA-seq counts was calculated for each gene across control or PD subjects in each cohort separately. a Representative scatter plots showing the adjusted promoter H3K27ac counts (X-axis), the adjusted RNA-seq counts (Y-axis) and the calculated Pearson’s correlation for three genes: MED13, PTPRH and DLG2 in control (blue) or PD (orange) individuals from the PW or NBB cohorts. Each dot represents an individual. Cor - Pearson’s correlation. b-e The distribution of correlations for all compatible genes was compared between the groups for various thresholds of minimal absolute correlation in either of the groups. Results are shown for PW (b, c) and NBB (d, e) cohorts. The number of genes that remained after applying the correlation threshold is shown in parentheses. The correlations remained closely distributed around 0 in PD subjects from both cohorts, regardless of the correlation threshold. c, e Median correlations in each group and the calculated Wilcoxon’s delta shift for the different correlation thresholds. f Nucleus-encoded mitochondrial genes exhibit negative correlation between promoter H3K27 acetylation and gene expression. Shown are examples for three mitochondria related GO terms

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